Chemical Exposure
3 important questions on Chemical Exposure
How does bisphenol A (BPA) affect the epigenome?
Mouse agouti model: shift coat color to yellow: DNA demethylation. Increased risk of developing obesity.
Supplementation with methyl-donating substances, ie choline/folic acid/vit B12, counters BPA effects.
Genistein (soy product) inhibits Dnmt activity-> DNA methylation
How does vinclozulin affect the epigenome?
How do HDAC inhibiotrs (HDACi) affect the epigenome, causing fetal valproate syndrome?
Affects retinoic acid (RA)-induced regulation of Hox-genes, which determine the basic structure and orientation of an organism. Affects anterior-posterior patterning.
Fetal valproate syndrome: subtle facial characteristics.
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