Schizophrenia spectrum and other psychotic disorders - biological theories
3 important questions on Schizophrenia spectrum and other psychotic disorders - biological theories
Why is the original dopamine theory now proved to be too simple?
- Many people with schizophrenia do not respond to phenothiazines
- if they respond: more relief positive symptoms than negative symptoms
- levels of dopamine change soon after start of medication, changes in symptoms take longer
- dopamine levels not only determinant
Which other neurotransmittors play an important role in schizophrenia?
- Serotinin neurons
- regulate dopamine neurons in mesolimbic system
- some of the newest drugs bind to serotonin receptors
- glutamate and GABA
- widespread in the brain
- deficiencies: cognitive and emotional symptoms
- glutamate: excitatory pathways
- drugs that block glutamate receptors cause hallucinations and delusions in healthy individuals
What is social drift?
Schizophrenia symptoms interfere with a persons ability to complete an education and hold a job, this results in people with schizophrenia to drift downward in a social class compared to the class of their family or origin
- chronically stressfull circumstances
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