The three R's of DNA metabolism - Elongation of DNA polymerases
3 important questions on The three R's of DNA metabolism - Elongation of DNA polymerases
What induces the switch from elongation to proofreading?
Deletion of aberrant base pair geometries within the double strand DNA binding site of the polymerase
What are the three possible things DNA polymerase can do?
1. Carry on with elongation
2. Proofreading
3. Release the template (inhibited by DNA clamps)
2. Proofreading
3. Release the template (inhibited by DNA clamps)
What are 4 characteristics of the DNA clamp PCNA?
1. Trimer
2. Biding sites for mRNA
3. RFC loads PCNA on primer of DNA
4. Has a central role in signaling chromosome replication fork status
2. Biding sites for mRNA
3. RFC loads PCNA on primer of DNA
4. Has a central role in signaling chromosome replication fork status
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