Cancer - Evading growth suppressors
3 important questions on Cancer - Evading growth suppressors
Which 3 mutations promote unregulated G1/S-phase passage?
1. Amplification of cylcin D
2. Loss of function mutation of p16
3. Loss of function mutation of Rb
2. Loss of function mutation of p16
3. Loss of function mutation of Rb
What is the effect of cyclinD amplification?
P16 cannot inhibit CycD
What is the effect of a loss of function mutation of p16?
Mimics overproduction of CycD1 leading to Rb hyperphosphorylation and E2F release
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