Cancer - miRNAs in cancer
3 important questions on Cancer - miRNAs in cancer
Which two miRNAs are causatively linked to cancer?
MiR15a and miR-16-1
What is the effect of miR15a/miR-16-1 cluster transfection in leukemia?
Significant reduction of BCL2 protein levels
When do the tumor suppressor functions of miRNAs manifest?
When their levels are reduced below critical levels, either by a reduction in a gene dosage or some other mechanism
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