LE 6: Post transcriptional gene control II - Exon junction complex (EJC)
3 important questions on LE 6: Post transcriptional gene control II - Exon junction complex (EJC)
What is the exon junction complex (EJC)?
A complex composed of several polypeptides, specific set of hnRNP proteins remain bound to the spliced mRNA
What is the nonsense mediated decay (NMD)?
An mRNA quality control mechanism to eliminate mRNAs containing premature stop codons
What is the process of NMD after the ribosome reaches the premature stop codon? (5 steps)
1. Ribosome stops translating
2. SURF binds the ribsomome
3. UPF1 is phosphorylated
4. Dissociation of release factor
5. MRNA decay
2. SURF binds the ribsomome
3. UPF1 is phosphorylated
4. Dissociation of release factor
5. MRNA decay
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