Read the summary and the most important questions on Aerobic Interval Training Versus Continuous Moderate Exercise as a Treatment for the Metabolic Syndrome

• 1 Clinical Perspective

• What is the effect of aerobic exercise training on the symptoms of the metabolic syndrome?

  Many, like insulin sensitivity, are improved.

• What is not yet known in the relationship between physical exercise as a therpay for the metabolic syndrome?

  The appropriate exercise intensity that generally yield maximal beneficial adaptations.

• What are the general risk factors of metabolic syndrome?

  • high cholesterol
  • physical inactivity
  • elevated blood pressure
  • dyslipidemia
  • impaired glycemic control
  • obesity
  • reduced endothelial function

• 2 Methods

• 2.3 Training Protocols

• What did the training protocol look like?

  frequency: 3x/week
  duration: 4x4mins hard, 3mins recovery, 5mins cooldown
  measure: 70% Hfmax
  total time: 16 weeks

• 2.4 Endothelial Function and Blood Pressure

• How was endothelial function measured?

  as flow-mediated dilation with vascular ultrasound.

• 2.6 Protein Phosphorylation and Expression Levels

• Which proteins and their phosphorylates were investigated?

  • Beta IR subunit (Insulin receptor)
  • Fatty acid transporter - 1
  • fatty acid synthase
  • PGC-1a
  • actin

• 2.7 Blood Analyses

• Which blood substances were investigated?

  • oxidized LDL
  • adiponectin
  • total NO
  • HOMA

• 4 Discussion

• 4.1 Aerobic Capacity

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• How was the mitochondrial capacity measured?

  • PGC-1a
  • SR Ca2+ ATPase

• Why is it adviced to improve fitness before aiming at losing weight?

  Both are independent prognostic markers of disease development.

• What may be the winning factor of AIT over CME in terms of adaptive response?

  The bigger changes in stroke volume that stimulate the arteries and heart.