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Drugs and Food - Powerpoint II

7 important questions on Drugs and Food - Powerpoint II

What is the U-shaped curve of DA?

Both low and high DA are associated with low cognitive performance
We all inherently want to optimise this bij using CNS stimulants or depressants or both.
Effects depend on:

Type and diffuculty task
Genetics predisposition
Type of drug (stim/depres)
Dosage, consumption history
Age, gender, disease, infection, immunity

What is the effect of amphetamine on val vs met on Wisconsin & N-back tasks?

Wisconsin Card Sorting Task:

Measured:

% preservation error ~ updating
BOLD signal ~PFC efficiency

What is the effect of a dosage of dopamine on chronic users on the Stop-Signal task?

Slower reaction time is worse. 0 and 300 are comparable, but worse than 100 and 200 mg.
Cocaine makes inhibition worse, the ability to stop drug use will be worse too because your inhibition is fucked up

How is Tyrosine effective in reversing DA depletion/stress?

Significant accuracy improvement on 2-back test, not on 1-back (bc 1-back is not stressful)

What is serotonin and it's effects?

Happy neurotransmitter
Associated with:

Sleep, mood, agression
OCD (reduced information processing)
Low - depression, autism, OCD
High - serotonin syndrome

Decreasing serotonin leads to:

Less affiliative behavior (social/emotional bonding)
Incresed aggression
Stronger response to seeing unfairness
Bias to negative stimuli

Tryptophan induces a +ve emotional bias?

Women were worse at recognizing disgust and better at happy faces.

1. Amphetamine effects PFC COMT-genotypes differently: - On AMP, Val-individuals show a/an _ in performance on __ type of tasks - At _ task load, Met-carriers on AMP perform _ than Val-carriers. 2. Long-term and Recreational drug users are than non-users in time-critical situations like _. Lifetime exposure to cocaine is correlated with the extent of this deficit. 3. In __ situations, Tyrosine supplements can _ DA depletion. 4. Reduced serotonin activity leads to less and more behavior. 5. is a supplement that is useful in reducing __ and promoting sleep.

Increse, sustained attention
High task load, Met on AMP perform worse
LT drug users are worse in time critical situations like driving, Coke is positively correlated
Stressful, reverse
affiliative, agressive
Tryptophan, anxiety