Biology of pathogens: Bacteria - Old microbial diseases
5 important questions on Biology of pathogens: Bacteria - Old microbial diseases
What are properties of cholera?
- Diarrheal disease
- caused by vibrio cholerae
- very rapid disease progression
- food and waterborne
What is the process behind diarrhea?
Toxin crosses membrane intestinal cell -> permanently activates G protein -> activated enzyme adenyl cyclase -> chloride channel -> large amounts of Cl, bicarbonate, Na and K secreted into lumen -> more osmotic pressure -> large amounts of water in lumen -> diarrhea and dehydration
What are the properties of the great plague (black death, bubonic plague)?
- Spread by fleas, vector disease
- yersinia pestis
- in lymphatic system, later in blood stream
- toxins
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What are the properties of leprosy?
- Chronic ID caused by mycobacterium leprae
- primarely affects skin, nerves and mucous membranes
- contact disease, splash borne
- incubation and treatment takes years -> multidrug therapy
What are the properties of tuberculosis?
- Caused by mycobacterium tuberculosis
- asymphtomatic, latent TB infection is most common (existent but not yet developed)
- airborne
- resurgence (reappears)
- treatment each 6-20 months
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