Clinical Microbiology and Immunology - Antibacterial Drugs
9 important questions on Clinical Microbiology and Immunology - Antibacterial Drugs
What was the first antibacterial drug?
What are the main principles of antimicrobial drugs?
- Must the microorganism lyse/kill/hinder
- Should not be easily broken down
- Should not affect the host (selective toxicity)
- Aiming at differences between prokaryotes/eukaryotes
- No or delayed resistance development
What are antimicrobial synthetic compounds?
- Growth factor analogs
- Quinolones
What are antimicrobial natural resources?
What are the main principles of antibiotics?
- Natural products produced by microorganisms can be used as antibiotics, in contrast with the synthetic compounds
- Microorganisms are also fighting with each other for a place in the habitat
- Gram-positives more sensitive than Gram-negatives, so, if both groups are sensitive: broad-spectrum antibiotic is used.
- Both eukaryote and prokaryote microorganisms are producers.
What is an example of a semi synthetic compound?
- Methicillin
- Oxacillin
- Ampicillin
- Carbenicillin
- Cephalosporins
What is the target of penicillin?
What is the mechanism of action of tetracycline?
What are examples of new antibiotics? What do they do?
Platensimycin inhibits lipid biosynthesis.
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