What is the positive effect of myokines on macrophages?
3 important questions on What is the positive effect of myokines on macrophages?
What myokines are involved in macrophages?
IL-6 --> inhibits TNF-alpha in adipose tissue and macrophages
IL-10 (anti-inflammatory) --> induces fat oxidation in adipose tissue
increased lipolysis --> more FFA in blood
What is the effect of myokines on atherosclerosis?
sedentary lifestyle --> low shear stress (blood flood --> stress on vascular walls) --> no mechanical receptors activated --> no activation of eNOS --> no NO --> ROS increases --> atherosclerosis
exercise --> other way around
What is the overall effect of exercise on inflammation?
exercise --> myokine production --> anti-inflammatory
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