Medicines by Design - Planning a synthesis
7 important questions on Medicines by Design - Planning a synthesis
What makes a good starting material for a synthesis?
Cheap and readily available
Why is the number of steps important in a synthesis?
The fewer the steps, the simpler the process
Suggest why optically active feedstocks, from natural sources, exist as one enantiomer.
Naturally occurring optical isomers have usually been produced at an enzyme's active site, which has a precise shape; this only allows one isomer to be produced.
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Why is the separation of a mixture of isomers difficult?
The isomers will have very similar properties e.g. boiling point
Give the formula for potassium chlorate (VII)
KClO4
Give the systematic name for Cu(AsO2)2 (pp jan 2011 Q2(b)ii)
Copper (II) arsenate (III)
Suggest the sequence of events that lead from one substance to the production of a synthetic stain for medical use (pp jan 2011 Q2 (e))
2. clinical trials
3. analyse/work out structure/ identify pharmacophore
4. synthesise (similar molecules)
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