Cognition in rodents
11 important questions on Cognition in rodents
Why are most of the time rodents or primates used in research?
Explain the development of a drug or protein.
Name the three R's of the ethical framework
Reduction: the use of as less animals as needed, or do more tests on one animal > produces low statistical power.
Refinement: makes it pleasant for the animal. This makes trustworthy outcomes.
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What are the three types of validity?
Predictive validity: animal predicts the way the compound will effect humans
Construct validity: the same biological processes are involved, you can test this with neurochemistry, anatomy, molecular pathways and genes
How to study a gene function
2. the foreign DNA (tested DNA) is placed in the ES cells of a brown mouse and is mixed with an embryo of a black mouse to produce offsprings
3. a GM mouse is born and its cognitive abilities are tested: through primary (observation), secondary (motor and sensory functions) and tertiary (specific behaviour) screening.
4. when they know which gene is affected they will test its learning and memory
What is the Barnes Maze and what does it test?
What is egocentric orientation?
What is the novel object recogntion test?
How to study executive functions like attention?
What is impuslive action, impulsive choice and impulsive decision making?
Impulsive choice: tasks of delay aversion
Impulsive decision making: reward time vs. what you get.
Name some examples of cognitive tests
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