Adaptief immuunsysteem
27 important questions on Adaptief immuunsysteem
What is the difference between B and T cells in function?
T cells interact directly with other immune cells
What enzyme is crucial for the rearrangement of gene segments in Lymphocytes?
WHat are the most abundant antibodies in the human body?
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What is the first type of immunoglobulin produced by an effector B cell?
Which antibody characterizes the secondary immune response of the adaptive immune system?
Make a rough estimate of lymph nodes in the human body
Which cell induces the adaptive immune response best? and where does this occur?
To fully activate a naïve T cell a dendritic cell has to signal 3 times. What are these signals?
- Antigen presentation to TCR
- Costimulation to induce proliferation and survival
- Cytokine signals to differentiate into specific effector subsets
How do pathogens try to evade the immune system?
- changing antigens
- inhibit immune response
- alter immune response
IgE is an antibody involved in allergies, but it also has another important role. What is this role for IgE?
Auto-immune diseases are usually rogue immune responses against the self. One cytokine in particular promotes the pro-inflammatory immune response, which one?
Tumor cells are great at inhibiting T-cell responses. A new immunotherapy (checkpoint inhibition) prevents the inhibitory effect of tumor cells on T-cells. How?
Where do B-cells reside inside the lymphoid organs?
What is the role of the spleen in adaptive immunity?
How do the lymphoid organs in the gut work?
How does negative receptor regulation in the adaptive immune system work?
Which immunoglobulin is the first to react?
B cells have 5 isotypes in their conservative part... what are they called?
Why do B cells have an isotype switch from IgM/IgD to IgG?
What is the main difference between MHC-I and MHC-II?
MHC-II shows EXTRACELLULAR components
Why is MHC so polymorphic?
What do the B cells do after they are stimulated by the T helper cells?
By which immunoglobulin is the second immune response characterized?
Which antibodies are most stable?
What is the difference between neutralisation and opsonisation?
opsonisation: bind with a caught bacteria to an Fc receptor, tagging it for destruction
Explain the immune response phase 1
- Antigen presentation
- Costimulation (CD28)
- Cytokine/ligands skewing
Explain the immune response phase 2 during infection:
Only 1 signal needed for effector function
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