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Summary Explaining How “High-Grade” Systemic Inflammation Accelerates Vascular Risk In...

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A snapshot of the summary - Explaining How “High-Grade” Systemic Inflammation Accelerates Vascular Risk in Rheumatoid Arthritis

  • 1 Intro

  • What are the keywords in this study?
    • Immune system
    • Inflammation
    • Artherosclerosis
    • Vascular risk
  • Which candidates for the high risk of CHD in patients with rheumatoid arthritis are investigated in this study?
    • inflammation
    • Dyslipidemia
    • Endothelial Dysfunction
    • Blood pressure
  • What is the risk of death in RA patients?
    70%
  • 2 Inflammation as a candidate pathway for CHD

  • Which molecule is a powerful measure of inflammation in synovial inflammation?
    CRP
  • What is said to explain about 30% of systemic inflammatory burden in RA?
    Adiposity
  • 3 Cytokines Have Extensive Metabolic Effects: Functional Pleiotropy

  • What is a consequence of the functional pleiotrophy of cytokines?
    That they mediate processes at different levels in an organism.
  • What are the pathways of pathogenesis in chronic inflammatory RA?
    • lipoprotein metabolism
    • insulin resistance
  • What is the main idea about the effect of cytokine intensity on the host?
    It fully depends on the biological context of the cytokine response. In the short term a cytokine burst can help against pathogens, but will in the long term work detrimental on organ function.
  • What is an interesting idea about the effect of IL-6 and leptin of host function?
    They pretty much act as hormones in that they will work  at very low levels, indicating that a rise in those cytokines can be damaging.
  • 4 From Synovitis to Accelerated Atherogenesis

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  • What pathologies can the cytokines TNF-a, IL-1b and IL-6 initiate in RA?
    • insulin resistance
    • dyslipidemia
    • prothrombotic effects
    • endothelial dysfunction
    • pro-oxidative stress
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