Celiac disease - an immunological perspective - Immunopathology of CD
3 important questions on Celiac disease - an immunological perspective - Immunopathology of CD
Which amino acid is abundantly present in gluten derived peptides?
Proline
Which 2 amidations occur in with celiac disease?
- Enzyme mediated: TTG changes (+)glutamine to (-)glutamic acids residues
- Acid-induced: in the stomach within 3h treatment of gliadin with gastric juice
The genes associated with celiac disease could be distributed in 4 categories
- Polarity and epithelial cell functionality
- Intestinal smooth muscles
- Growth and energy homeostasis
- Innate and adaptive immune response
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