T6: Chemical carcinogenesis
10 important questions on T6: Chemical carcinogenesis
What is the difference between banign tumors and malignant tumors?
Malignant they are poorly differentiated and there is a lot of infiltration. There is no capsule and it grows fast. There is also necrotic tissue, the damage is much more severe.
Active tumour suppressor -> inactive tumour suppressor
What are proto-oncogenes and oncogenes?
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What are tumor suppressors and what happens when they are inhibited?
What is true about induction of cancer by aflatoxin B1 ?
What are the steps of getting a cancer cell?
What are important carcinogenic chemicals ?
-Polycyclic hydrocarbons
How can chemicals cause canCer?
There could be defined a threshold/save level of exposure for non-genotoxic carcinogens, they do not interact directly with the DNA.
Three stage in the process of carcinogenesis are called:
-invasion
-metastasis
How do non-genotoxic chemicals infect the DNA?
no direct damage
no interaction or metabolite with DNA.
But some can still cause cancer.
They cause cell death and aberrant repair. They can effect the repair system. They can effect the metabolism of chemicals (P450) they can effect cell growth. Also hormonal systems can be effected and de induction of the production of ROS.
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