T5: Genetic toxicity
13 important questions on T5: Genetic toxicity
What is the difference between endogenous and exogenous mutations?
Exogenous mutations can come from industrial chemicals, drugs, food contaminations or UV radiation. Diet has a big influence!
What are the consequenses of a mutation in a germinal cell?
What can be genotoxic compounds?
- Clastrogens: compounds that cause structural chomosomal aberrtions
- Aneugens: compounds that cause numerical chomosomal aberrations.
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What are the different types of mutations?
Insertion: and extra nucleus is added
Deletion: a nucleus is removed.
Insertion and deletion give a franeshift mutation.
What is chromosomal aberration? Structural (clastrognes)
Error prone repair
incorporation of random nucleotides to fill up a lesion
What is chromosomal aberration? Numerical (aneugens)
This causes severe diseases or miscarriage.
What happens when a compoundinds to the DNA?
What are the indirect routes that can lead to genotoxicity?
They could be ROS mediated, this can cause influence on the gene transcription or cell proliferation.
What is an in vitro test called The Ames test?
not correct....
What is the in vitro Mammalian gene mutation test?
In vitro chromosome aberration test?
What is tested in vivo?
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