Intestinal homeostasis in health and disease - Pattern recognition receptors and inflammatory signaling
3 important questions on Intestinal homeostasis in health and disease - Pattern recognition receptors and inflammatory signaling
What is the structure of TLRs and how does it work?
- Extra cellular domain with LRR (leucine-rich repeats
- Short transmembrane domain
- Highly coserved intracellular domain - the Toll-interleukin 1 receptor (TIR)
LRRs bind to MAMPs and contribute to dimerization of receptors. This leads to recruitment of adaptor molecules (MyD88, TIRAP and TRIF) to initiate the signaling cascade.
What is the structure ov NOD?
contain a N-terminal caspase recruitment domain (CARD) a nucleotide bdingin ologomerization domain (NOD) and a C-terminal regulatory domain with mitiple LRRs that bnd to peptidoglucan fragments in the cutosol.
How is adaptive immunity regulated in protecting the mucosa?
This is orchestraed by IECs with antigen-presenting cells (APCs) and lymphoid cells. This occurs in the GALT.
Aggegrated in Peyer´s patches (PP).
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