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A snapshot of the summary - Harrison's Endocrinology, 3E
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2 Disorders of Anterior Pituitary and Hypothalamus
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What makes the treatment of hormone-excess syndromes caused by malfunction of the anterior pituitary elusive?The differences in clinical manifestation of the diseases are usually fairly subtle.
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2.1.1 Anatomy
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What makes the major artery from the hypothalamus to the pituitary suitable in terms of transmission?The hypothalamic-pituitary portal plexus allows reliable transmission of peptide hormones to the pituitary without systemic dilution of the peptides.
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By which atery is the Neurohypophysis supplied?By the inferior hypophyseal arteries.
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What makes intrasellar pathological processes exceptionally dangerous?They have a big chance of inflicting vascular and neural damage to the brain.
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Where is the pituitary located?In the sella turcica (just below the hypothalamus)
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What is the main difference in innervation by the hypothalamus between the Anterior pituitary and the Neurohypophysis?The Anterior pituitary is innervated by the hypothalamic-pituitary portal plexus by which it receives hypothalamic hormones. In contrast, the Neurohypophysis is Directly innervated by the hypothalamus.
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Which part of the pituitary is more sensitive to damage of the pituitary stalk?The Neurohypophysis, as this part of the pituitary is directly innervated by the hypothalamus through the stalk.
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2.1.2 Pituitary Development
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What makes Pit-1 an important transcription factor in the development of the pituitary?Pit-1 determines cell-specific expression of GH, PRL and TSH
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2.2 Hypothalamic and anterior pituitary insufficiency
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How is Hypopituitarism acquired?
- inherited disorder
- inflammation
- tumors
- vascular damage to the pituitary arteries
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2.2.1.1 pituitary dysplasia
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Which disorders may result from pituitary dysplasia?midline craniofacial disorders
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The following topics are covered in this summary
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anterior, pituitary, development
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syndrome, abnormalities, bardet-biedl
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cranial, irradiation, hypopituitarism
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deficiency, manifest, diabetes
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prolactinomes, thermoregulation, hypothalamus
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prolactine, diameter, prl
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adh, threshold, water
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renal, vasopressin, water
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oxytocin, people, production
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di, primary, polydipsia
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fluid, threshold, avp
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di, avp, pituitary
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hypernatremia, body, fluids
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hyponatremia, water, avp
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thyroid, cells, medullary
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tsh, hormones, hormone
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thyroid, tsh-r, hypoplasiacongenital
