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Summary HNH-23306

Course
- HNH-23306
- Renger Witkamp
- 2019 - 2020
- Wageningen University (Wageningen University, Wageningen)
- Voeding en Gezondheid
277 Flashcards & Notes
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A snapshot of the summary - HNH-23306

  • L1 general introduction; terms and definitions

  • What is a drug?
    • Medicines
    • bio-actives
    • chemicals
  • L2 Molecular Pharmacodynamics and receptor pharmacology

  • Different classes of receptors (4)
    • Ligand-gated ion channels 
    • G-protein-coupled receptors 
    • protein kinases
    • transcription factors 
  • What is asthma (in brief)
    Recurrent and reversible airway obstruction 

    • inflammatory changes in the airways
    • bronchial hyper-responsiveness
    • attack in two phases 
  • What are examples for pharmacology of asthma
    • Beta 2 - adrenergic agonists relax smooth muscle 
    • short acting (salbutamol) or long acting (salmeterol)
    • usually given as local formation 
    • use depends on type of asthma, often combined with glucocorticoids 
    • sometimes: muscarinic receptor antagonist 


    - not that common anymore: PDE inhibitors 
  • The general principles of drug action: receptor models
    Hangt ervan af of het een agonist of antagonist is en of het occupation governed by affinity (L->R)of activation governed by efficacy (B->O) is
  • L3 Pharmacokinetics deel 1

  • How do compounds cross the intestinal epithelium?
    • Paracellular transport 
    • transcellular transport 
    • active or carrier mediated 
  • The expression/activity of cytochrome P450 (CYP450) is dependent on:
    • Genetics 
    • gender
    • age 
    • diet
    • smoking 
    • environment 
    • diseases
    • medicines etc 


    geen grapefruit eten want dan wordt P450 geblokkeerd!
  • Where can ion trapping be used for?
    Ion trapping can be used to distribute drugs into the urinary compartment to increase/decrease the urinary excretion of poisons/drugs etc 

    • arlkalinization of the urine (by administration of sodium bicarbonate) to increase urinary excretion of acetyl salicylic acid
    • idem to reduce urine levels of illicit drugs with basic properties (cocaine, amphetamine, morphine...)
  • How many liter water is in your total body
    60-70%

    30-40 liters 
  • L4 Pharmocokinetics deel 2

  • What does it mean when your Vd is 0,2 L/kg; 0,55 L/kg; >1 L/kg
    Vd 0.2 L/kg 
    • total extracellular volume 
    • polar / very hydrophilic compounds 
    • e.g. Vecuronium, gentamicin, carbenicillin, many biopharmacuticals 



    Vd 0.55 L/kg
    • total body water 
    • e.g. Ethanol, phenytoin 


    Vd > 1 L/kg
    • lipophylic compounds
    • for example compounds acting in the CNS
    • diazepam 
    • mianserin 
    • trimipramine 
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