L3 Pharmacokinetics
3 important questions on L3 Pharmacokinetics
The expression/activity of cytochrome P450 (CYP450) is dependent on:
- Genetics
- gender
- age
- diet
- smoking
- environment
- diseases
- medicines etc
geen grapefruit eten want dan wordt P450 geblokkeerd!
Where can ion trapping be used for?
Ion trapping can be used to distribute drugs into the urinary compartment to increase/decrease the urinary excretion of poisons/drugs etc
- arlkalinization of the urine (by administration of sodium bicarbonate) to increase urinary excretion of acetyl salicylic acid
- idem to reduce urine levels of illicit drugs with basic properties (cocaine, amphetamine, morphine...)
How many liter water is in your total body
60-70%
30-40 liters
30-40 liters
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