L6 food-drug interactions
4 important questions on L6 food-drug interactions
Take drug on .. Full stomach or empty stomach?
- Delayed gastric emptying --> decreased absorption rate
- effect on bio-availability depends on (a.o.):
- acid stability
- dissolution behaviour in stomach omhoog/omlaag
Effects of high fat meals on drug absorption
- Fat delays gastric emptying --> absorption also delayed
- with hydrophilic compounds, effects on bio-availability usually less pronounced
- lipophilic compounds often affect bio-availability, but not always in a similar direction
Specific diets and eating habits; problems may be expected with:
- Supplements containing much calcium, magnesium, iron or zinc
- vitamin-preparations
- fibers
- herbs
- extensive weight loss
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Drug-food interaction ...key massages
- Chronic drug use is often associated with malnutrition and deficiencies
- polypharmacy is an important risk factor and elderly are specifically at risk
- causality often not clear
- awareness of apparent drug-food interactions can help to improve patient care
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