Secondary Lymphoid Organs and Lymphocyte Trafficking
7 important questions on Secondary Lymphoid Organs and Lymphocyte Trafficking
(Secondary lymphoid is) highly organised and acts as a filter for the lymph
- T and B cells enter through HEV (from blood) or via the lymph
- Antigen (opsonized) can enter via the lymph or already inside DCs
- Lymph comes in through Marginal sines which is carpeted with macrophages (eat antigens)
T cell independent activation of B cells
- Early in infection. Antigens decorated with complement end up in the lymph node
- follicular DCs catch them and present them to B cells
- once a B cell recognizes the antigen: proliferation and activation --> IgM
- But also uptake of the antigen and MHC II presentation
- Move to T cell zone, no Cell, B cell apoptosis
- Move to T cell zone, T cell that is activated by same antigen, survival of the B cell
T cell-dependent activation of B cells
- Antigen presenting cells (DCs) MHC II present antigen to T cells, these T cells proliferate and differentiate
- T cells become Th1, Th2 etc
- Upregulate CD40L and
- secrete cytokines
- which give the B cell class switch signals
- Plasma cell formation and correct Ig produced.
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Kenmerken/eigenschappen van secondary lymphoid organs
- Brings lymphocytes and antigen presenting cells together
- maximises the activation
- each lymphoid organ drains a specific site (spleen--> blood) and the immune cells found there are most likely to respond to the antigens present at that site
concept of homing!
What is the advantage of T cell independent activation over T cell dependent activation?
What is an immunological synapse?
What are the two functions of Th cells ar regards to the functioning of CTLs?
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