General - Cytokines - IL-4
3 important questions on General - Cytokines - IL-4
Which interleukins can induce eosinophilia?
- IL-4
- IL-5
- IL-13
- IL-5
- IL-13
What is the source of IL-4?
T cells (especially Th2), mast cells, basophils, and bone marrow stromal cells.
What is the function of IL-4?
- Promote naïve T cell differentiation to Th2 cells and its proliferation
- Stimulates the growth and differentiation of B cells.
- Induces class switching to IgE.
- Promotes allergic responses
- Macrophages: alternative activation and inhibition of IFN-y mediated classical activation
- Proliferation of mast cells
- Stimulates the growth and differentiation of B cells.
- Induces class switching to IgE.
- Promotes allergic responses
- Macrophages: alternative activation and inhibition of IFN-y mediated classical activation
- Proliferation of mast cells
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