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Summary IM-H

- Advanced Molecular Immunology and Cell Biology
- 2020 - 2021
- Vrije Universiteit Amsterdam
- Biomedical Sciences
305 Flashcards & Notes
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A snapshot of the summary - IM-H

  • 1 Elements of the immune system and their role in defense

  • What is the immune system?
    A diffuse, complex network of interacting cells, cell products and cell-forming tissues that protect the body.
  • What happens to the immunity balance in case of disease?
    - non self harmful can cause an infection
    - non self harmless can cause an allergy
    - self harmless can cause an auto-immune disease
    - self harmful can cause cancer
  • How to treat immune related disease in other words how to restore the balance between inflammation and tolerance?
    - in case of infection: vaccines 
    - in case of  autoimmune disease or cancer: the immunotherapy
  • 1.1 Innate versus adaptive immunity: components

  • What are the epithelial barriers?
    Physical barriers from the first line of defence against pathogens.
  • What are the secondary lymphoid organs and the function?
    Activation of adaptive immune cells. 
    -  Lymph nodes 
    - Spleen 
    - Gut Associated Lymphoid Tissues (GALT)
  • What is correct concerning your innate immune system?
    It forms the first and the second line of defence
  • 1.2 Innate versus adaptive immunity: function

  • What is the function of innate immune cell receptors?
    - used for activation and pathogen uptake 
    - equal expression per cell subset 
    - can differentiate between major pathogen species
    - using associated molecular patterns: >pathogen (PAMPS) >danger(DAMPS)
  • What is the function of the adaptive immune cell receptors?
    - used for activation and effector functions 
         > B cell: B cell receptor BCR becomes soluble: antibody
        >T cells: T cell receptor TCR  
    - can differentiate within major pathogen species
    - using antigens 
       > highly specific for each pathogen 
       > receptor is highly specific per cell
  • Neutrophils are recruited by macrophages from the...
    Bone marrow by chemokines
    Note: recruit then chemokine
  • 2 Immediate response to infection: complement

  • 2.1 Inflammation complement

  • What is the function of the alternative pathway?
    Activates soluble C3 convertase starting with hydrolysis
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