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• Questions week 1

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• One of the main functions of MHC molecules is to:A) Transduce the signal to the T-cell interior after antigen bindingB) Mediate class switching of immunoglobulinC) Present antigen for recognition by T-cell antigen receptorD) Stimulate the production of interleukinsE) Bind complement

  C. Present antigen for recognition by T-cell antigen receptor

• What molecule is expressed by antigen presenting cells that activate T helper cells?A) T cell receptorB) B cell receptorC) Class I Major Histocompatibility Complex moleculesD) Class II Major Histocompatibility Complex moleculesE) NK cell receptor

  D) Class II Major Histocompatibility Complex molecules

• How do T cells recognize antigen?A) In a three-dimensional formB) In solution in the plasmaC) Follwoing presentation by pattern recognition receptorsD) When presented on the surface of antigen presenting cells

  D) When presented on the surface of antigen presenting cells

• Which of the following is the best method to reduce the effect of graft vs. host disease in a bone marrow recipient?A) Remove mature T cells from the graft tissueB) Administer IFN alphaC) Match the complement components of donor and recipientD) Remove pre-B cells from the graft tissue

  A) Remove mature T cells from the graft tissue

• Which of the following statements on MHC molecules is correct?A) Class II MHC molecules are involved in antige-dependent lymphocyte differentiationB) Class II MHC molecules are important for the binding of foreign antigen to ommunoglobulin on B cellsC) Class I MHC molecules are composed of two polymorphic chainsD) Class I MHC molecules exhibit promiscuous binding of peptides, while class II MHC molecules do not

  A) Class II MHC molecules are involved in antige-dependent lymphocyte differentiation

• The products of TAP genesA) Bind to ERAPB) Prevent peptide binding to MHC moleculesC) Are part of the proteasomeD) Transport peptides from the cytosol to the ER to bind to MHC class IE) Transport peptides into the ER to bind to MHC class II

  D) Transport peptides from the cytosol to the ER to bind to MHC class I

• Which of the following statemenst on a bacterial protein in the lysosome of a macrophage is not true?A) Processing of the proteint will result in the production of possibly immunogenic peptides that associate with MHC class II moleculesB) The pathway used by the bacterial protein is most often used for exogenous antigensC) The protein could lead to the activation of CD4+ T cellsD) The protein could lead to the activation of CD8+ T cellsE) Removal of CLIP from class II MHC molecules would allow the bacterial peptide to bind to MHC

  E) Removal of CLIP from class II MHC molecules would allow the bacterial peptide to bind to MHC

• Which statement about the polymophism of major histocompatibility genes is true? Polymorphism:A) Is observed in MHC-II genes but not in MHC-I genesB) Allows the MHC molecules to bind to either CD4+ or CD8+ T cellsC) Results in variability in peptide binding of MHC moleculesD) Occurs as a result of gene rearrangements in individual cellsE) Determines whether antigens are processed by the endocytic or endogenous pathway

  C) Results in variability in peptide binding of MHC molecules

• Which MHC molecules will be expressed on B cells in an individual with the following MHC genes: A1, A4, C3, B7, B13, DR4 and DR8?A) A1, C3, B7 and DR4 on half of the B cells, A4, C3, B13, and DR8 on the other halfB) Only DR4 and DR8C) Only A1, A4, C3, B7 and B13D) All genes except C3E) All genesF) You cannot tell without knowing the haplotype of the parents

  E) All genes

• What is true about class I MHC molecules?A) Expression of MHC-I molecules is not regulated by cytokines, because the MHC-I molecules are always presentB) An alpha and beta chain form the cleft to bind antigensC) MHC-I molecules associate with the invariant chain in the ERD) A non-variable region binds to the CD8 molecule on a T cell during antigen recognition

  D) A non-variable region binds to the CD8 molecule on a T cell during antigen recognition