Motor control - Cerebellum
10 important questions on Motor control - Cerebellum
Where do the most corticofugal fibers go to?
Where do the corticofugal fibers go to from the pons?
To what does the cerebellum project to?
the thalamic nuclei projects back to the (pre)motor cortex
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How many times are the fibers crossed over to the other side?
How is the tract that leaves from the (pre)motor cortex called?
Which two types of afferent axons go to the cerebellum?
- carry information to cerebellum from many sources
- excitatory projection to central cerebellar nuclei and granule cells (=parallel fibers) in cerebellar cortex
- many parallel fibers need to be activated to activate Purkinje cell
- carry error-signal to cerebellum from inferior olivary nucleus
- excitatory projection to central cerebellar nuclei and Purkinje cells in cerebellar cortex
- one AP of climbing fiber is enough to activate Purkinje cell because the climbing fibers are tightly wrapped around Prukinje cells
How does error signaling work?
Where do purkinje cells project to?
(mossy fibers also project to the cerebellar nuclei (and parallel fibers))
What is the difference between simple and complex spikes?
- leads to typical AP if many are activated
Complex = Purkinje cells stimulated by climbing fibres
- leads to one broad atypical spike followed by a silent period
What happens if climbing and parallel fibers are active at the same time?
The strength of the parallel fiber is decreased by internalizing AMPA receptors (via PKC) --> long term depression
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