Motor control - Striatum
11 important questions on Motor control - Striatum
What is the circuit of the extrapyramidal system?
Which neurotransmitters are used in the extrapyramidal circuit?
Glutamate (excitatory)
Which two subcircuits excist in the extrapyramidal system?
To the subthalamic nucleus (from the pallidum)
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Which NT are used in the subcircuit from the striatum to the substantia nigra?
Dopamine (in this case excitatory)
Which NT are used in the subcircuit from the globus pallidus to the subthalamic nucleus?
Glutamate (+)
What is the function of the globus pallidus in the striatal circuit?
What happens when the subthalamic nucleus is defect?
What is the result of a defect in the subthalamic nucleus?
- Ballism -> finging movements of extremities, throwing/kicking like
o Subthalamic nucleus defect at one side = hemiballism
o Dissapears over night, because there is no tone of the muscles
o Hemiballism can largely dissappear spontaneously
§ Other subthalamic nucleus takes over the control (plasticity of brain)
What is the function of the substantia nigra?
What if the dopaminergic neurons in the substantia nigra degenerate?
What is the result if the substantia nigra degenerates?
- Parkinsons’ disease
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