Organisation and model systems
3 important questions on Organisation and model systems
What triggers regeneration and what distinguishes it from normal differentiation pathway?
MAPK activation leads to phosphorylation of ERK —> p-ERK translocates to the nucleus — > expression of target genes
If generic wound healing signals are the prerequisite for regeneration, then why doesn’t regeneration occur in all animals?
ERKi blocks regeneration. With wounds signals, regeneration is induced.
Tools to target signaling pathways
- Microfluidics
- Optogenetics
- Temperature modulation
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