Biochemistry thrombosis and homeostasis - Primary hemostasis
7 important questions on Biochemistry thrombosis and homeostasis - Primary hemostasis
What is primary hemostasis?
- comprises VWF dependent adhesion of blood platelets
What are the crucial role of vascular endothelial cells?
- Barrier function
- Storage organelles for platelet-binding von Willebrand factor
- bio-active components
What are Von Willebrand factor used for?
- Polymers to caputre as much blood platelets possible
- Helicostructure (fold in circulation), when needed they unfold and the VWF filament is released to caputre platelets
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How are blood platelets made?
- Megakaryocytes within the bone marrow from cytoplasmic protrusion which cross the endothelial cell barrier and are subsequently releases as proplatelets in the circulation.
- Proplateltes develop into platelets
What are the 2 states of blood platelets?
- Resting state
- Activated/aggregated state ("glue")
What are the 3 platelet deficiency?
- GP1b deficiency
- GP2b deficiency
- VWF deficiency
- Type 1/3: absence or decrease of VWF
- Type 2A: multimer structure affected
- Type 2B: binding to platelets affected
- Type 2N: binding to FVIII affected
- Type 2M: binding to collagen affected
What is Thrombotic thrombocytopenic purpura (TTP)?
- normally cleaves VWF multimer into small pieces
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