Allergic Contact Dermatitis (ACD); basal and clinical (retesting) dr. T. Rustemeyer ACD - Immune regulation / Tolerance VUmc, Dermatologie ACD - Socioeconomical impact / Occupation-associated skin diseases
25 important questions on Allergic Contact Dermatitis (ACD); basal and clinical (retesting) dr. T. Rustemeyer ACD - Immune regulation / Tolerance VUmc, Dermatologie ACD - Socioeconomical impact / Occupation-associated skin diseases
What does the horny layer of the skin consist of?
Which size does a contact allergen need to have in order to penitrate the skin, and how is it called?
How is the skin build?
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What important protein is present in the skin?
Filaggrin mutations: a risk factor of fragrance allergy ?
Name the two types of DCs in the skin
What does a Langerhans cell bind to?
What is PPD and where can you find it?
How turns PPD into what?
Name an example of a thiolgroup that activates a Langerhans cell
Name an example of a aminogroup that activates a Langerhans cell
What does the TLR on DCs do, and what does it consist of?
How does the induction of danger signal by allergens such as Nickel work?
How does the inflammasome gets activated by Irritant potential of contact allergens?
Why do mice hardly get sensized to nickel?
What increases sensitizing potential of nickel?
What sensitization potency of nickel in mice?
In what plays NF-kB a role, and what does it activate?
What can you add to sensitization potency?
What do dermal DCs activate, and LCs suppress?
Name 5 properties of contact allergens determining their sensitizing power
Name some examples of contact allergens:
Name some Examples of non-contact allergens:
Why is Identification of contact allergens in dendritic cell based assays important?
Name the characteristics of Allergic contact dermatitis:
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