Rheumatoid Arthritis dr. C. Verweij Clinical aspects / Pathology / Risk factors / Epidemiology VUmc, Pathologie Biomarkers
34 important questions on Rheumatoid Arthritis dr. C. Verweij Clinical aspects / Pathology / Risk factors / Epidemiology VUmc, Pathologie Biomarkers
What is Rheumatoid arthritis?
What characterizes the pathopathophysiology of the joint in RA?
What are the auto-antibodies in RA?
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What is the flowchart measurements biomarker discovery?
How does the flowchart measurements biomarker discovery go?
What is an advantage of transcriptomics?
What is the procedure of cluster analysis of mircoarray?
What is the procedure of SAM of mircoarray?
Background-colorWhat is the procedure of PAM of mircoarray?
What is the procedure of SOURCE of mircoarray?
What is the procedure of Pathway analyses/Gene-set level analyses of mircoarray?
What is the whole procedure of microarray?
What is know about the etiology of RA?
What is a multifactorial disease, and why is RA one?
Name biomarkers in preclinical RA
Gene signatures in peripheral blood cells implicated with risk to develop arthritis involve:
What is the Logistic regression of Transcriptome biomarker to predict risk for development of arthritis?
What is the Type I IFN signature of RA?
What can type I IFNs do?
Which cells are present in follicular subtype RA
Which cells are present in diffuse and aggregate subtype RA?
Molecular and histochemical tissue subtypes in RA: Name the characteristics of immune-mediated RA
Molecular and histochemical tissue subtypes in RA: Name the characteristics of immune-independent, stromal RA
IFN comprises three major groups:
Which type IFN is associated with a number of autoimmune diseases? Name 4 diseases.
Which genes are overexpressed in (RA)?
Name 7 IFN type I pro-inflammatory activities
Name 4 IFN type I anti-inflammatory activities
IFN type I pro‐ or anti‐inflammatory effect in RA?
Name 5 Targeted Therapies in RA
What are the 8 effects mediated by TNF-α?
Which gene signatures characterize preclinical RA?
What predicts non-response to rituximab in RA=
What does rituximab regulates in RA, which is associated with responder status?
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