Epithelial-Mesenchymal transition (EMT) - Cell biology and behavior in EMT
3 important questions on Epithelial-Mesenchymal transition (EMT) - Cell biology and behavior in EMT
What are the characteristics and cellular changes associated with EMT?
- embrynonic cell migration
- wound healing
- cancer cel verspreiding
- activatie of EMT-TFs
- E-cadherin respression
- loss-apico-basal polarity
- invasion and migration
- low proliferation
- intravasation en extravasation
- chemotherapie resistant
- inflammation
What are the core transcription factor (TF) that induces EMT? What is E- to N-cadherin switch?
Twist TF
E- to N-cadherin switch allows interaction with various mesenchmal cell types
- loss of epithelial markers
- gain of mesenchymal markers
E- to N-cadherin switch allows interaction with various mesenchmal cell types
- E-cadherin: Epithelial state
- N-cadherin: Mesenchymal state
What are the characteristics and cellular changes associated with MET?
- Organ differentiation
- epithelial homeostasis
- metastatic colonization
- repression of EMT-TFs
- E-cadherin transcription
- apico-basal polarity
- cell-cell adhesion
- increased proliferation
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