Therapy of renal tubulopathies
8 important questions on Therapy of renal tubulopathies
What is the urine composition?
How is the volume of the kidney determined?
Which forms are transport are there in the kidneys & explain them
- Paracellular = between cells
- Claudin 10 (medulla) --> lets through Na+ (HELIX syndrome)
- Claudin 14/16/19 (cortex) --> lets through Mg2+ (FHHNC)
- Transcellular = through the cells
Passive transport --> tight junctions (leaky), carriers, channels
Active transport --> primary (Na-K-ATPase), secondary
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What does the glomerular filtration system consists of?
- Podocytes --> slit diaphragm in between
- basal membrane + glycocalyx (- charge)
- epithelial cells of the blood
Of what does a bio-artificial kidney consists?
Name the 4 Renal Replacement Therapies (RRT)
- Bio-artificial kidney
- Stem cells / organoids
- whole organ bioengineering
- 3D bioprinting
What are the manifestations of drug-induced kidney disease (DIKD) or drug-induced nephrotoxicity (DIN)
- Acid-base abnormalities
- electrolyte imbalances
- proteinuria, pyuria (white blood cells in urine), hematuria
- Decline in the GFR
How can kidney diseases be diagnosed?
- urinalysis --> volume, pH, glucose, proteins, cells
- blood test --> blood urea nitrogen (BUN), creatinine
- histopathology
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