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Summary Neuronal-Glia Mechanisms Of Exercise-Evoked Stress Robustness

Course
- Scriptie
- Yannick Mahieu
- 2016 - 2017
- Vrije Universiteit Amsterdam
- _TEACHER_GENERAL_
32 Flashcards & Notes
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A snapshot of the summary - Neuronal-Glia mechanisms of Exercise-Evoked Stress Robustness

  • 1 Introduction

  • What is stress robustness?
    1. stress resistance
    2. stress resilience
  • What does stress resistance mean?
    Stress resistance means that you can endure a greater intensity or duration of a stressor before the suffering starts
  • What does stress resilience mean?
    Stress resilience means that you recover more quicky from the negative consquences after exposure to a certain stressor.
  • How can stress robustness be influenced?
    • nature of stressor
    • organism characteristics
  • Which organism characteristic is the topic of this study?
    Physical activity status
  • What is the hypothesis of this study?
    a physical active lifestyle promotes stress robustness in the face of intense uncontrollable stress.
  • What are the fundamental assumptions made to support the hypothesis?
    Physical activity promotes stress robustness by modulating the CX3CR1-CX3CL1 axis between neurons and microglia.
  • What will be the expected differences between the physical active group and the sedentary group in response to intense uncontrollable stress?
    Sedentary mice will respond more vigourously to stress with excessive serotonin, noradrenalin and prolonged downregulation of the CX3CR1-CX3CL1 axis.

    Physical will respond less vigourously to stress with controlled serotonin, noradrenalin and rapid recovery of the downregulation of the CX3CR1-CX3CL1 axis.
  • 2 Consequence of Intense Uncontrollable Stressor Exposure

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  • What are the common brain adaptations following Intense Uncontrollable Stress exposure?
    • sensitisation of the serotonergic system
    • activation of the noradrenergic system
    • increases in hippocampal inflammatory cytokines (IL-b, TNFa)
    • increases in microglia proliferation and activation
    • decreases in neuronal CXCR1 mRNA
    • decreases in hippocampal neurogenesis
    • decreases in plasticity-associated markers (BDNF)
  • Which brain functions are decreased after exposure to uncontrollable stress?
    • hippocampal neurogenesis
    • plasticity marker expression
    • CX3CR1 expression
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