L5 Synaptic basis of neuroplasticity
11 important questions on L5 Synaptic basis of neuroplasticity
On which kind of neuron are AMPA and NMDA receptors found? Inhibitory or excitatory?
Identity of neurons is not about the receptors they express but about the neurotransmitters they release.
What is the result on the plasticity by over-expression of NMDA receptors?
What is Long term synaptic potentiation (LTP)?
- Higher grades + faster learning
- Never study anything twice
- 100% sure, 100% understanding
For my 1st exam I got a C. Then, I started looking for ways to learn better and I came across Study Smart. Since then I have scored a A+, A, A- and another A. I highly recommend it to everyone who wants to hear it. I am so happy with it!!
I was struggling to finish all my first-year subjects for 3 years. Then I discovered Study Smart, which helped me to finish all of them within 3 months.
Because of StudySmart, things are going well in many ways. Before, I always had study stress and no time for anything. Now I feel calm and confident (because of the program). I used to score a B, now I usually score an A or A+.
Hey Chris, I really want to thank you very much for developing the platform, I usually got around C for my exams, now I scored an A+, an A and a A- !!
Since using Study Smart, my average has increased significantly. I even completed a statistics course with a A+ while I'm bad at statistics. I took on extra courses this year, because of Study Smart. Thanks so much!
Ever since I started studying with StudySmart I passed all my exams !!! No more re-sits!! At first, I was happy with a pass and now I only get good grades. Many thanks!
I aced all the courses I studied with Study Smart. For law, I first scored a D, and now an A! I’m 100% sure that I’ll pass all the courses I study with Study Smart.
I always thought I studied well. My grades were fine. I could never have imagined that applying these study skills would have such a huge and direct impact on my grades, my speed and the pleasure I have in learning.
For the first time, I finally feel totally confident about the way I learn. I have the perfect overview and make great progress in terms of speed and the grades I get. Thanks, Chris!
I immediately started to enjoy learning again, and my grades soared. All of a sudden, everything went better. I highly recommend Study Smart to all students..
Being able to create my materials online made the process of studying so much smoother and quicker. I no longer have to spend a huge amount of my time on creating my summaries.
At first, my notes were a mess. Now I use Study Smart to take my notes in a perfectly structured way. It helps me to save a lot of time and do other things I enjoy.
Students that study with Study Smart get better grades. The system applies all the learning methods in such a way that both well-performing students and students who struggle perform much better.
Hi Chris, I would like to thank you very much. Last year I scored C on a course, and this year I got an A+ thanks to your method! Thank you very much!
The largest effect is that my child is more enthusiastic about school! Every parent wants their children to be happy at school, Study Smart made it happen.
In high school, I failed several exams, and that has really changed now. I actually needed this tool very much back then. Since I started studying with StudySmart, I haven't had any D's. My average score is now an A and those are results I would have never had in the past
With my old method, I passed only 3 out of 8 courses. Since I started taking my notes digitally in Study Smart, I have passed all my courses on the first try. For me, StudySmart takes away the stress of wondering if I will pass or not.
Thanks to StudySmart, I passed all my exams, and with better grades than before! On top of that, I have mastered a very good study method now, which I am confident will help me earn my degree.
Which of the following is NOT a common feature of LTP in the CNS?
1. LTP can persist for months in vivo
2. Induction but not maintenance of LTP requires gene translation
3. Maintenance but not induction of LTP requires gene transcription
4. Strong stimulation induces long-lasting potentiation
5. Weak stimulation induces short-lasting potentiation
2, 3
Feature:
1, 4, 5
note: induction but not maintenance of LTP requires gene transcription; maintenance but not induction of LTP requires gene translation
induction LTP -> gene transcription
Maintenance LTP -> gene translation
(zelfde aantal i'tjes)
What are the four step in induction of the Long-term synaptic potentiation ?
- Activation of NMDA receptors
- Increased postsynaptic calcium
- Activation of CaMKII
- Enhancement of AMPA receptor function
What are two forms of long-term synaptic plasticity?
- Physiological: Change in the efficacy of synaptic connectivity
- Best studied in vitro brain slices using electrophysiological methods
- Relevant amount of change in long-term efficacy (long-term potentiation (LTP) vs Long-depression (LTD)) is a direct measure of synaptic strength.
- Anatomical: Addition and removal of synaptic connections between neurons
- Best studied in vivo, in intact brain circuits by longitudinally visualising synaptic connections
- Change in the synaptic count, shape of synapses, turnover rate and motility reveal anatomical nature of synaptic connectivity
It is generally accepted that a synapse should first express physiological plasticity to express anatomical changes.
What is the central dogma of synaptic plasticity? (Donald Hebb 1849)
Neurons that fire together wire together.
means the more you run a neural-circuit in your brain, the stronger that circuit becomes. ... The more you practice piano, or speaking a language, or juggling, the stronger those circuits get. Scientists have known this for years.
In other words, the simultaneous activation of neurons strengthens the connection between them
What mechanism could mediate synapse specificity of plasticity?
- tags
What does postsynaptic injection of active CaMKII fragment potentiate?
What are methods for conditional up-regulation of LTP - making a smarter mouse
- Over-express NMDA receptors - improve LTP and spatial memory (on Morris Water Maze)
- Inhibit Calcineurin (is phosphatase) - should improve LTP and spatial learning performance (on the Morris Water Maze)
The molecular mechanisms of NMDA mediated enhancement of LTP
- Over-express NMDAR
- when the intracellular calcium concentration rises moderately
- A phosphate "Gate" modulates CaMKII signaling
- the gate is controlled by cyclic AMP
- Blocking PKA should reduce LTP as increased intracellular calcium will no longer inactivate PP1a action (so PP1a must be inactive for LTP)
- LTP is blocked by a PKA inhibitor and rescued by active inhibitor-1
- If the Gate is held open by directly activating the cAMP pathway
- If the Gate is held open by directly activating the cAMP pathway... Even weak stimulation induces LTP
- should improve LTP
Try our study magic for free
a PDF, study it super fast
- No sign up, email or credit card needed!
- AI makes unlimited flashcards
- Get unlimited quizzes and tests
- Ask AI anything
- No sign up, email or credit card needed!
- Have and keep perfect overview
- Make flashcards, notes and mind maps
- Review, test and score!
The question on the page originate from the summary of the following study material:
- A unique study and practice tool
- Never study anything twice again
- Get the grades you hope for
- 100% sure, 100% understanding
