Diet-treatment interactions
10 important questions on Diet-treatment interactions
What are the key elements when talking about diet-treatment interactions
- Nutrition determines treatment outcomes, also by modulating drug (side-) effects
- Vice versa, treatment can affect nutritional status
- Various mechanisms can be involved
- Prediction is not always easy: unexpected outcomes often occur
What are the effects of gastric emptying
- Delayed emptying may slow down of absorption
- The total amount (finally) absorbed may differ and depend amongst others on
- acid stability
- dissolution rate
What are the issues of diet-treatment interactions
- Food - drug interactions basics
- Don's take these drugs with ...
- Effects of cancer chemotherapy on nutrient intake and kinetics
- Body composition and drug effects and vice versa...
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Interactions prior to administration
- Gastric emptying, residence time and pH effects
- Drug distribution and elimination
- Binding, decomposition in the GI tract
Effects of food (and food-supplements) on drug action (2)
- Pharmacokinetic interactions (changes in ADME)
- Pharmacodynamic interactions
Processes determining oral bioavailability
What are the effects of high and low fat meal on Lapatinib
take lapatinib at least 1hr before or 1 hr after a meal. Take it the same moment relative to your meal every day
Drug-induced smell and/or taste disorders
mechanisme rather diverse
- cytotoxicity
- neurotoxicity
- taste aversion
- effects on food reward
- effect on saliva
- bad taste
Effect of Dietary Antioxidants on Reactive Oxygen species (ROS)
Vit C can increase the antioxidant levels but from the other antioxidants it is not known
Changes in ADME resulting from cachexia
- Impaired gut wall function
- Malabsorption
- Reduced fat tissue and lean body mass
- Hypoalbuminemia and increased concentration of alpha-1-acid glycoprotein
- changed expression of metabolising enzymes and drug transporters
- Impaired renal function
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