Age-related changes in muscle physiology
4 important questions on Age-related changes in muscle physiology
What is the atrophy of a muscle fiber?![]()
- Epimysium
- Tendon
- Bone
- Perimysium
- Blood vessel
- Muscle fiber
- Fascicle
- Endomysium
Surgery results in muscle mass loss, how?
- Muscle serves as a protein-pool to deal with surgical stress
- Surgery is usually followed by bed-rest
- This leads to muscle atrophy
- 3.4% loss in quadriceps CSA during 1 week of hospitalization
- 1.5 kg loss in whole body lean mass during 10 days of bed rest
Short-term internventios are needed to lower the muscle mass loss when having surgery. What is needed?
- Time window of training: 30 days
- Current effective strategies take > four months
- two systematic reviews conclude
- rehabilitation is a promising idea
- but there is a need to explore effective interventions, including nutrient supplementation, of maximum 30 days
4-week exercise AND nutrition
- 2 days per week: supervised training
- 30 minutes resistance exercise
- 30 minutes HIT
- 5 days per week: adhere to exercise guidelines
- 2x 15g milk-protein per day
- 1 arm pre-post design, n=17
- no planned surgery
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What is the conclusion of the 4-week Exercise AND nutrition study
- 4 weeks of intense exercise + protein supplementation improves muscle mass, strength and physical performance
- Possibly effective to prevent hospital-induced losses in muscle mass and strength
- Application for preoperative patients should be further explored
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