Study material generic cover image

Summary Osteorheumatology: A New Discipline?

44 Flashcards & Notes
Scroll down to see the PDF preview!
PLEASE KNOW!!! There are just 44 flashcards and notes available for this material. This summary might not be complete. Please search similar or other summaries.
  • This + 400k other summaries
  • A unique study and practice tool
  • Never study anything twice again
  • Get the grades you hope for
  • 100% sure, 100% understanding
Remember faster, study better. Scientifically proven.
Trustpilot Logo

A snapshot of the summary - OsteoRheumatology: a new discipline?

  • 1 Introduction

    This is a preview. There are 2 more flashcards available for chapter 1
    Show more cards here

  • What is the basic idea underlying OsteoRheumatology?
    The importance of the crosstalk between inflammation, cartilage and subchondral bone in disabling conditions like OA and RA.
  • 2 Bone involvement in OA

    This is a preview. There are 1 more flashcards available for chapter 2
    Show more cards here

  • What is the hallmark of osteoarthritis?
    Destruction of cartilage
  • What are the keywords in osteoarthritis?
    • cartilage
    • subchondral bone
    • synovial membrane
    • low-grade inflammation
    • estrogen-deficiency
    • wear
    • local
  • 3 The role of subchondral bone in OA

    This is a preview. There are 5 more flashcards available for chapter 3
    Show more cards here

  • What are the typical skeletal changes in OA?
    • increased cortical plate thickness
    • flattening and deformation of the articular contour
    • bone marrow lesions
    • decreased subchondral trabecular bone mass
    • tidemark duplication
    • osteophyte formation
  • Where is subchondral bone located?
    Below the cartilage of the joints and has same properties as the epihyseal plate (growth plate)
  • Which two phenotypes can be distinghuised as a result of increased subchondral bone remodeling?
    1. Sclerosis
    2. Osteoporosis
  • How is a sclerotic phenotype induced?
    By mechanically overloading the subchondral bone on the osteochondral junction.
  • How can a subchondral osteoporotic phenotype be induced?
    • estrogen deficiency or menopause
    • stress shielding
    • synovial inflammation
  • What can be said about the quality of the subchondral bone in OA?
    The quality is low because the bone is hypomineralized (has probably to do with a collagen type that has low affinity for Calcium).
  • What is said about the osteoblast cytokine production?
    It has increased production of both bone stimulating and bone degradation signaling cytokines.
PLEASE KNOW!!! There are just 44 flashcards and notes available for this material. This summary might not be complete. Please search similar or other summaries.

To read further, please click:

Read the full summary
This summary +380.000 other summaries A unique study tool A rehearsal system for this summary Studycoaching with videos
  • Higher grades + faster learning
  • Never study anything twice
  • 100% sure, 100% understanding
Discover Study Smart