Indtoduction - Survival strategies
6 important questions on Indtoduction - Survival strategies
Which interesting features do trypanosomatids have?
2. It has a kinetoplast (mini+maxi circle DNA)
3. It has mitochondrial RNA editing
What are difficulties with covering the entire surface with one single protein (VSG)? And how can they overcome them?
2. You need a molecular mechanism for antigenic variation. To overcome this, the parasite has 1. In situ switch, 2. Telomere exchange and 3. Gene conversion
What are survival strategies of ascaris?
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Do all parasites have a fermentative metabolism?
What are survival mechanisms of protozoal parasites?
2. Intracellular location, so hidden from immune system
3. Manipulation of host immune system
How does schistosoma survive in the bloodvessel for years?
2. Mimicry: binding host components on surface
3. Immune modulation by excreted factors (Th2, Treg)
4. Anti-thrombotic activity: inhibition of platelet activation
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