Study material generic cover image

Summary Pathology

Course
- Pathology
- dr. S. Amor
- 2021 - 2022
- Vrije Universiteit Amsterdam
- Gezondheid en Leven
635 Flashcards & Notes
Scroll down to see the PDF preview!
  • This summary
  • +380.000 other summaries
  • A unique study tool
  • A rehearsal system for this summary
  • Studycoaching with videos
Remember faster, study better. Scientifically proven.
Trustpilot Logo

A snapshot of the summary - Pathology

  • Lecture 1 - Ch2: Cell injury, cell death and adaptations

  • What are the consequence of damage?
    1. It can be reversible
    2. Lead to adaption
    3. Lead to death of the cell 
  • What happens with myocardial hypertrophy?
    1. Mechanical stretch. Induction of embryonic genes. It increases the mechanical performance and decreases the work load. 
    2. Agonist. It increases the synthesis of contractile proteins and thereby increase the mechanical performance.
    3. Growth factors.  It increase the production of growth factors. 
  • What happens where there is oxygen shortage?
    The cell swells because of failure of Na/K ATPase
  • Which form of cell death is anti-inflammatory?
    Apoptose
  • Triggers extrinsic apoptosis-induction
    A lethal signal from outside the cell (FasL, TNF) triggers through receptor activation a cascade that leads to apoptosis.
  • Describe the extrinsic apoptosis pathway
    1. Ligand binds
    2. Adaptor proteins bind via death domain and recruit and activate caspase-8
  • Triggers mitochondrial (intrinsic) pathway of apoptosis-induction
    • Lack of survival signals
    • Damage
    • Stress of cell 
  • Describe intrinsic pathway
    1. BH3 sensors the triggers
    2. It inactivates the Bcl-2 family 
    3. Activation of BAX/BAK channels
    4. Cytochrome C and other pro-apoptotic proteins leak out the mitochondria
    5. They activate caspase 9 
    6. Apoptosis 
  • What is the cause of follicular lymphoma?
    Loss op apoptosis-response by overexepression of BCL2-gen
  • What are the functions of cytochrome C?
    1. Electron transport in oxidative phosphorylation
    2. Induction apoptosis 
Read the full summary
This summary. +380.000 other summaries. A unique study tool. A rehearsal system for this summary. Studycoaching with videos.