Summary: Powerpoints Immunotech | Tijhaar

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Read the summary and the most important questions on Powerpoints Immunotech | Tijhaar

  • 1 Innate Immune System

    This is a preview. There are 17 more flashcards available for chapter 1
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  •  What are differences in receptor diversity between innate and adaptive immune system?  

    innate receptors are germline-encoded, adaptive receptors are made via gene rearrangement and thus more different.

  • What are cellular components of the immune system?  

    granulocytes, macrophages, DCs and NKs

  • How are acute phase proteins induced?

    TNF alpha, IL 6 and IL1

  • What effects does the complement system have on bacteria and cells?

    bacteria: lysis, opsonisation

    cells: phagocytosis, degranulation of mast cells

  • Describe the pathway of complement activation.  

    The pathogen effects C3 in such a way that is decomposes. C3b coats the pathogen to facilitate phagocytosis. Cytokines are formed that decompose C5 and activate C9, which forms the Membrane attack complex to destroy the pathogen


  • What are Type I Interferons?  

    INF alpha and beta, are produced by infected cells after TLR activation so neighbour cells differentiate into an anti-viral state.

  • Which functions do granulocytes have?

    neutrophil: kill phagocytosed microbes, promote inflammation

    eosinophil: produce histamine to induce vasodilation, increase capillary permeability and chemotaxis

    basophil: recruit immune cells, extracellular killing of large microbes


  • Which cytokines are produced by macrophages and DCs?

    IL 1, IL6, IL8 and TNF alpha

  • Into which cells can macrophages differentiate?

    CNS: microglia

    liver: Kupffer cells

    lung: alveolar macrophages

    bone: osteoclasts

  • Which cytokines stimulate monocytes to become macrophages or DCs?  

    macrophages: monocyte colony stimulating factor

    DCs: FIt3

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