Summary Principles of exercise testing and interpretation : including pathophysiology and clinical applications Book cover image

Summary Principles of exercise testing and interpretation : including pathophysiology and clinical applications

- Karlman Wasserman
ISBN-10 1609138996 ISBN-13 9781609138998
181 Flashcards & Notes
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A snapshot of the summary - Principles of exercise testing and interpretation : including pathophysiology and clinical applications Author: Karlman Wasserman ISBN: 9781609138998

  • 1 Exercise Testing and Interpretation

  • 1.1 Cell respiration and bioenergetics

  • Name the 3 mechanisms for energy supply.
    1. Aerobic (O2-requiring) oxidation of substrate (glycogen and fatty acids)
    2. Anaerobic hydrolysis of PCr (phosphocreatine)
    3. Anaerobic oxidation of glycogen or glucose (forming lactate)
  • Which energy mechanisms is responsible for the O2-deficit and O2 debt during recovery?
    The anaerobic hydrolysis of PCr
  • In what way does PCr contribute to ATP regeneration?
    A reservoir of PCr is present in the muscle.
    1. PCr splits in Cr and Pi. P can bond with ADP to form ATP again. 
    2. It also acts a a shuttle to translocate Pi from the mitochondria towards the myofibril. 
  • What happens when the cell becomes O2 poor?
    During the glycolysis NAD+ is reduced to NADH + H+. When there is no O2 present to 'catch' the protons (H+), the H+ binds to pyruvate which makes lactate (NADH + H+ --> NAD+ +lactate).
  • Does the splitting of PCr increases the cell's acidity or decreases it?
    PCr is a relatively strong acid, so when it splits to Cr (which is neutral) the cell becomes less acidic
  • How many protons are produced with each lactate ion?
    1 H+
  • By with molecule is the H+ (produced by lactate) buffered during anaerobic glycolysis?
    By HCO3  - (bicarbonate)
  • Why does the PCr reaction consumes CO2?
    Because the splitting of PCr makes the cell less acidic, H20 + CO2 --> H2CO3 --> HCO3 - + H+. The H+ in this reaction brings the cell acidity back to basic values (?)
  • 1.2 why measure gas exchange to evaluate..

  • welke reacties kunnen gemeten worden met cardiopulmonary exercise testing(CPET)
    reacties in de cellen, in het cardiovasculaire systeen en ventilatoire systeem
  • What 3 system can be measured simultaneously with CPET?
    1. The cellular system
    2. Cardiovascular system
    3. Ventilatory system
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