Immune defence of mammals against bacterial pathogens - Phagocytic defenses
3 important questions on Immune defence of mammals against bacterial pathogens - Phagocytic defenses
Sequence of phagocytosis events
1. Delivery of PC's to site of infection
2. Phagocytic adherence to the target
3. Ingestion of particle
4. Phagolysozome formation
5. Intracellular killing
6. Intracellular digestion
2. Phagocytic adherence to the target
3. Ingestion of particle
4. Phagolysozome formation
5. Intracellular killing
6. Intracellular digestion
Chemokines and interleukins (IL)
Cell signalling molecules made by immune cells such as IL-8 and CCL20
Two methods that neutrophils use to kill invading pathogens
1. Engulfment of microbes
2. Secretion of antimicrobial peptides (disarming pathogens)
2. Secretion of antimicrobial peptides (disarming pathogens)
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