Bacterial Colonization and Invasion - Biofilms
3 important questions on Bacterial Colonization and Invasion - Biofilms
3 Stages of the biofilm lifecycle
1. Free-floating become attached to a surface
2. EPS production allows for development of a complex structure
3. Biofilms can propagate through detachment of small clumps of cells, forming a new one somewhere else
2. EPS production allows for development of a complex structure
3. Biofilms can propagate through detachment of small clumps of cells, forming a new one somewhere else
Manipulate quorum sensing
Inhibition of quorum sensing with QS inhibitors or anti-QS peptides has also been found to reduce biofilm formation.
Modify bacterial second messenger
Bacterial second messengers are important for lifestyle changes, so for example motile to sessile switch --> modulating these pathways could also be an option
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