Disease of the immune system - Cell and Tissues of the immune system
3 important questions on Disease of the immune system - Cell and Tissues of the immune system
Describe T cell activation, by MHC class II
MHC class II presents the peptide antigen to a CD4+ T cell (T-helper cell). The antigen is presented to TCR and CD4 binds to the MHC class II molecule, this results in signal 1. However, a second signal is needed, which is the CD80 (APC) binding to CD28 (T-cell)
What is the function of T-helper cells
- Activation of T- and B-cell
- inflammation through production of cytokines
- Activation of macrophages
Decribe T cell activation by MHC class I
MHC class I presents the peptide antigen to a CD8+ T cell. This activation induces a cytotoxic response, causing apoptosis in a target cell, hence the name cytotoxic T lymphocytes (CTLs)
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