Inflammation and repair - Overview of inflammation: definitions and general features
7 important questions on Inflammation and repair - Overview of inflammation: definitions and general features
Which leukocytes emigrate predominatly in acute inflammation
Name the external manifestations of inflammation (cardinal signs)
in Latin: calor, rubor, dolor, functio laesa
What are the main components of inflammation?
vascular reaction and a cellular response; both are activated by mediators that are derived from plasma proteins and various cells.
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Wanneer wordt inflammatie beëindigd?
The steps of the inflammatory response (5 R's)
- recognition of the injurious agent
- recruitment of leukocytes
- removal of the agent
- regulation (control) of the response
- resolution (repair)
Hoe gaat het 'rolling' in z'n werk?
Selectins gaan als eerst te werk. Zitten voornamelijk op leukocyten. Maar door de cytokinen worden P-selectins ook beschikbaar op het endotheel. (ze zitten anders in de cel)
Ze hebben een lage affiniteit met de leukocyten. Waardoor ze los en vast zitten en dus rollen. Door de blood flow gaan ze weer los.
Dit proces heet ook wel diapedesis.
De liganten voor de selecties zijn:
sialic acid-containing oligosaccharides bound to glycoprotein backbone.
Wat zijn neutrophil extracellular traps? En bij welk proces zijn ze betrokken?
Wordt gedaan door neutorfiel granulocyten.
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