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A snapshot of the summary - samenvatting human infecious diseases
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1 Lecture 1 + 2
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What is a virus?The smallest genetic entities.
A piece of genetic information with a protein coat that hijacks' the host cells and replicates itself -
What are the 3 main characteristics of viruses?
- Infectivity
- penetrate and multiply in host cell
- Obligate intracellular parasite
- cannot replicate by itself, no protein synthesizing machinery or energy producing machinery
- property to survive outside a living cell in an extracellular state
- in an inert state or via carrier, depends on environment
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A virus is composed of
- Nucleic acid
- RNA or DNA
- SS or DS
- segmented or non segmented
- protein shell
- assembled form smaller subunits: coat proteins
- lipid membrane / viral envelope
- some viruses
- made from host cell
- Nucleic acid
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All viral RNA
genomes are __1__ (linear/circular) except for __2__1 = Linear
2 = viroids -
The properties of the viral genetic material depends onThe family to which the virus belongs
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The minimal virus needs the 2 genes:
- DNA/
RNA-polymerase - multiplication of RNA or DNA genome
- coat protein
- protection and host interaction
- DNA/
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The viral genomes varies between (nucleotideS)2,000 - 1,000,000
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What is mutation rateThe number of necleotides per 1000 nt of genome length that mutate per year
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What affects the mutation rate?
- The nature of the genetic material
- RNA viruses mutate quicker than DNA viruses
- number of generation per year
- The nature of the genetic material
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Why do RNA viruses mutate quicker than DNA virusesDNA polymerase has proofreading whereas RNA polymerase doesn't
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The following topics are covered in this summary
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proteins, coat, virus
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rna, virus, mrna
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influenza, cells, respiratory
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cells, cleavage, proteases
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virus, hev, food
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cell, cells, virus
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vaccines, virus, vaccine
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iron, deficiency, supplementation
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malaria, mosquitos, mosquito
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resistance, cell, bacteria
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q-fever, coxeilla, bacterium
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baculovirus, expression, protein