Cell specification, determination and morphogenesis
10 important questions on Cell specification, determination and morphogenesis
Explain the term 'cell specification'
Cell specification is a term for the phenomenon of the embryonic cell being capable to differentiate autonomously when it is placed in a neutral environment. This means that there is something instinsic to the embryonal cell that makes sure it can specify.
What are the (3) modes of cell specification?
Explain the term 'autonomous specification (mosaic)'.
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Explain the term 'conditional specification'.
Explain the term syncytial specification
What does the transplantation experiment of Spemann and Mangold show?
What is the difference between determination and specification?
What is a fate map?
In which ways can positions of cells change?
Extension: cells move away from each other (and extend)
Intercalation: cells 'mix' with each other (radial and medio-lateral)
Which cell adhesion molecules are there and what do they attach?
CAMs: calcium independent cell-cell adhesion
Integrins: cell-ECM adhesion
Extracellular matrix molecules (collagen, fibronectin, laminin & tenascin): bind to integrins.
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